Whitley Bay have already booked themselves a place in the semi-finals of the competition with an impressive 3-1 win over Newcastle United u21s under the floodlights at Hillheads.
Lewis Orrell, Andrei Ardelean and Malky Morien were on target for the Northern League Seahorses with Michael Ndiweni netting for the Premier League Magpies young guns.
The Bay were 3-0 winners at Blyth Town in round one.
The remaining games to see who will make up the last four are all scheduled to take place this week.
Newcastle Benfield host Morpeth Town at Sam Smith’s Park on Tuesday 13th December.
Northern League Benfield will be looking to surprise the Highwaymen, of the Northern Premier League Premier Division, and will be full of confidence following their 2-0 first round victory at Bedlington Terriers.
Morpeth’s League form is somewhat out-of-sorts lately with them suffering a run of defeats that have also seen them fail to hit the target, so they will hope to take a springboard from the tie.
Heaton Stannington take on Ashington in an all-Northern League affair at Grounsell Park on the evening of Wednesday 14th December.
The Stan advanced to this stage with a 3-2 win over Prudhoe YC while the Colliers recorded a 3-1 success at West Allotment Celtic.
With a side containing the likes of Robbie Dale and Dan Maguire, who lifted the trophy last season, Ashington will be looking to reach the final for the first time since they last won it in 2012/13.
A mouth-watering tie between North Shields and Blyth Spartans takes place on Friday 16th December.
The Robins, who play in the Northern Premier League (East), beat Newcastle University 3-1 in round one.
Blyth, of the National League North, are the holders of the Techflow Marine Senior Cup and the highest-ranked side in Northumberland so will be keen to return to St. James’s Park for the County showpiece again this season.